Play Pill Roulette Now
Experience the thrill of pharmaceutical Russian roulette. Will you survive?
What is Pill Roulette?
Pill Roulette, also known as Side Effects, is a tense, turn-based survival game where you face off against an opponent in a high-stakes medical trial. Each round, you are presented with a set of pills. Some are beneficial, some are placebos, and some are lethal. Your goal is to survive longer than your opponent by making calculated choices, using experimental items, and managing your body's resistance to the drugs. One wrong move, and it's game over.
How to Play
Take Your Pills: Each turn, you must choose a pill. Will it help you or harm you? The choice is a gamble.
Manage Your Resistance: Every pill you take affects your resistance. If it drops to zero, you die. You must balance the risk and reward of each dose.
Use Items Wisely: Between rounds, you can acquire experimental items. These can range from vaccines that heal you to tools that can give you an edge over your opponent. Use them strategically to shift the odds in your favor.
Outlast Your Opponent: Your opponent is intelligent and will use bluffs and their own items to try and outwit you. You need to read their moves and adapt your strategy to be the last one standing.
Pro Tips & Strategies
Mastering Pill Roulette requires more than luck. Here are some expert strategies to improve your chances in this intense pharmaceutical duel.
Resistance Management
Monitor your resistance closely in every round. If it drops below 3, prioritize healing or defensive items to avoid sudden death.
Strategic Item Usage
Use items strategically to counter your opponent's moves. Save drug tests for rounds with more dangerous pills on the table.
Effective Bluffing
Bluff effectively to mislead your opponent. Act confident when taking risky pills to make your opponent doubt their strategy.
Pattern Recognition
Learn pill patterns to make better decisions. The game follows certain distribution rules that you can exploit with experience.
Timing is Everything
Save your most powerful items for critical moments when your resistance is low. A well-timed vaccine can turn the tide of the game.
Opponent Analysis
Pay attention to your opponent's behavior to predict their next move. Their patterns can reveal their strategy and resistance level.
Game Elements
Pill Types
Green Pill
Heals 1 resistance point. These beneficial pills can save you in critical situations.
Yellow Pill
No effect, completely harmless. Perfect for bluffing or when you need to play it safe.
Red Pill
Damages 1 resistance point. The most common harmful pill you'll encounter.
Purple Pill
Damages 2 resistance points. A significant threat that can quickly turn the tide of the game.
Gray Pill
Damages 3 resistance points. Extremely dangerous and can lead to immediate defeat if resistance is low.
Black Pill
Instant death, regardless of resistance. The ultimate threat in the game - avoid at all costs.
Strategic Items
Vaccine
Provides immunity to the next pill's negative effects. Essential for surviving high-risk rounds.
Drug Test
Reveals the type of a pill before consumption. Knowledge is power - use this to make informed decisions.
Mouth Restraint
Forces your opponent to take a pill of your choice. A powerful offensive tool to control the game.
Candy
Looks like a pill but has no effect. Perfect for bluffing and psychological warfare.
Antidote
Removes the effect of the last pill taken. A lifesaver when you've just consumed something dangerous.
Hammer
Destroys a pill, removing it from the current round. Use this to eliminate suspected dangerous pills.
Gameplay Videos
Experience Pill Roulette in action through these curated gameplay videos showcasing different endings, strategic item usage, and advanced gameplay mechanics.
All Endings & Items Showcase
This comprehensive guide demonstrates all possible endings in Pill Roulette and showcases the strategic use of each item in the game.
Let's Play Pill Roulette
Watch this exciting gameplay walkthrough to see the tension and strategic decision-making in high-stakes Pill Roulette matches.
Frequently Asked Questions about Pill Roulette
Get answers to the most common questions about Pill Roulette gameplay, mechanics, and features.
Pill Roulette (also known as Side Effects) is a tense, turn-based survival game where players take turns consuming pills with unknown effects in a twisted medical trial. It's inspired by Buckshot Roulette but with a pharmaceutical twist.
Outlast your opponent by managing resistance, using items strategically, and making calculated decisions about which pills to take. If your resistance drops to zero, you die. Monitor your opponent's behavior and adapt your strategy accordingly to gain the upper hand.
The full version includes both single-player against AI and a multiplayer mode (2 players). The web version on this site is primarily single-player. The multiplayer mode offers an even more intense experience as you face off against human opponents.
The game features 6 different pill types, each with unique effects. Some heal you, some harm you, and some can kill you instantly if your resistance is too low. Learning to identify and strategize around these pills is crucial for survival.
The game includes 9 unique items such as vaccines (to heal), mouth restraints (to force your opponent to take a pill), drug tests (to identify pill effects), and more. These items can be acquired between rounds and should be used strategically to maximize their effectiveness.
Yes, the game features multiple endings depending on your performance and choices throughout the game. Each ending provides unique insights into the game's narrative and characters.
The game is available on itch.io and is coming to Steam. You can wishlist it on Steam to be notified when it launches. Follow our social media for announcements about platform availability and upcoming features.